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Thumbi Ndung’u

Director for basic and translational science, Africa Health Research Institute (AHRI)
Professor Thumbi Ndung'u is an eminent HIV scientist who has made important contributions in the field of HIV vaccine and pathogenesis research. His research programme at AHRI is focussed on understanding how HIV and TB persist and replicate in the face of a hostile host immune system – with the goal of aiding the design of a safe, affordable and effective HIV-1 vaccine or effective immune-based therapies. Thumbi has a special interest in capacity building for biomedical research in Africa, primarily through the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) programme, based at AHRI. He is a Max Planck Society Group Leader and holds a professorship at the University of KwaZulu-Natal.

He is interested in understanding antiviral immune mechanisms and viral adaptation in HIV-1 subtype C infection as a pathway to vaccine development. His work has focussed on understudied populations and viral strains in resource-limited, high burden settings where knowledge of the role of antiviral immune responses, viral strains and associated genetic factors is likely to yield the greatest impact in terms of biomedical interventions like vaccines. Thumbi’s early work addressed the lack of biological tools for HIV vaccine and pathogenesis research on HIV-1 subtype C, the predominant subtype globally and in southern Africa. He generated and characterised the first infectious molecular of HIV-1 subtype C from primary isolates, and constructed the first infectious subtype C envelope-derived simian-human immunodeficiency virus able to replicate in rhesus macaque peripheral blood mononuclear cells. These tools were deposited in the NIH AIDS reagent program and remain available to researchers. The tools have facilitated in vitro and animal model studies of HIV-1 subtype C biology and vaccine development research.

Economy

Putin in Delhi: Assessing the Stakeholders. A Comprehensive Examination of Defence, Energy, and Aspirations for Export Expansion."

With discussions spanning new S-400 regiments, cooperative Su-57 fighter and hypersonic technology, and long-term agreements on Russian crude, LNG, and nuclear initiatives, Putins visit to Delhi places defence and energy...

Asian Currencies Steady as Rupee Hits Record Low Amid Fed Rate Cut Bets

Most Asian currencies held steady on Thursday after modest gains, as markets continued to price in the possibility of a Federal Reserve rate cut next week. The US Dollar Index edged 0.1% higher following an overnight dip...

Asian Markets Mixed as Fed Rate Cut Bets Grow and Japan’s Nikkei Leads Gains

Asian stock markets traded mostly subdued on Thursday, mirroring the modest uptick seen on Wall Street as investors positioned themselves ahead of next weeks Federal Reserve meeting. Market sentiment remained cautiously...

China Urged to Prioritize Economy Over Territorial Ambitions, Says Taiwan’s President Lai

Taiwan President Lai Ching-te has urged Chinese President Xi Jinping to direct his focus toward revitalizing Chinas weakening economy rather than pursuing territorial expansion, highlighting widening economic contrasts...

IMF Deputy Dan Katz Visits China as Key Economic Review Nears

International Monetary Fund Deputy Managing Director Dan Katz is making his first trip to China since leaving his position as chief of staff to U.S. Treasury Secretary Scott Bessent, marking a significant moment ahead of...

Politics

Cuba Reaffirms Anti-Drug Cooperation as Tensions Rise in the Caribbean

Cuban authorities announced that the island is intensifying its fight against narcotics trafficking in the Caribbean, emphasizing ongoing cooperation with the U.S. Coast Guard despite heightened political tensions and an...

Drones Spotted Near Zelenskiy’s Flight Path in Ireland Trigger Security Alert

An Irish naval vessel detected as many as five drones operating close to the flight path of Ukrainian President Volodymyr Zelenskiys aircraft as he arrived in Ireland for a state visit, according to local media reports on...

Australia Progresses AUKUS Review as U.S. Affirms Strong Support

Australia is moving forward with the newly received United States review of the AUKUS nuclear-powered submarine partnership, signalling renewed confidence in the trilateral defence pact with the U.S. and the United...

Trump Administration Tightens H-1B Visa Vetting With New Focus on Free Speech and Censorship

The Trump administration has introduced stricter vetting measures for H-1B visa applicants, targeting professionals in highly skilled fields often recruited by major U.S. tech companies. According to an internal State...

California Launches Portal for Reporting Alleged Misconduct by Federal Immigration Agents

California has introduced a new online portal that enables the public to submit videos, photos, and other evidence of potential misconduct by federal immigration agents. The initiative comes as immigration enforcement...

Science

Senate Sets December 8 Vote on Trump’s NASA Nominee Jared Isaacman

The U.S. Senate Commerce Committee announced it will vote on December 8 on President Donald Trumps renewed nomination of private astronaut and tech entrepreneur Jared Isaacman to lead NASA. Isaacman, known for his...

NASA Cuts Boeing Starliner Missions as SpaceX Pulls Ahead

NASA has significantly scaled back Boeings Starliner program after years of technical issues and delays, announcing that the next Starliner mission to the International Space Station (ISS) will fly without astronauts. The...

Blue Origin’s New Glenn Achieves Breakthrough Success With First NASA Mission

Blue Origins massive New Glenn rocket marked a major milestone as it completed its first mission for paying customers, sending two NASA satellites toward Mars and successfully landing its reusable booster at sea. The...

Cogent Biosciences Soars 120% on Breakthrough Phase 3 Results for Bezuclastinib in GIST Treatment

Cogent Biosciences (NASDAQ: COGT) shares skyrocketed over 120% after the biotech company announced groundbreaking results from its Phase 3 PEAK trial evaluating bezuclastinib in combination with sunitinib for patients with...

Trump and Merck KGaA Partner to Slash IVF Drug Costs and Expand Fertility Coverage

U.S. President Donald Trump and German pharmaceutical company Merck KGaA have announced a groundbreaking deal aimed at lowering the cost of in-vitro fertilization (IVF) treatments while boosting access to fertility care in...

Technology

EU Prepares Antitrust Probe Into Meta’s AI Integration on WhatsApp

The European Commission is reportedly preparing to launch a new antitrust investigation into Meta Platforms Inc. (NASDAQ: META) over the companys recent rollout of artificial intelligence features within WhatsApp....

Sam Altman Reportedly Explored Funding for Rocket Venture in Potential Challenge to SpaceX

OpenAI CEO Sam Altman reportedly explored raising significant capital to acquire or partner with a rocket company, a move that could have created direct competition with Elon Musks SpaceX. According to a report from the...

Wikipedia Pushes for AI Licensing Deals as Jimmy Wales Calls for Fair Compensation

Wikipedia is seeking additional licensing deals with major technology companies to address the growing financial burden caused by artificial intelligence firms heavily scraping its platform, according to co-founder Jimmy...

Firelight Launches as First XRP Staking Platform on Flare, Introduces DeFi Cover Feature

Firelight reaches 25M XRP deposit cap within hours of launch; ushers in a new era for decentralized XRP staking. A new XRP staking platform, Firelight, has officially launched on the Flare blockchain, marking the first...

OpenAI Moves to Acquire Neptune as It Expands AI Training Capabilities

OpenAI has confirmed plans to acquire Neptune, a startup known for its advanced tools that help companies track, monitor, and optimize AI model training workflows. Although the company did not release the financial details...