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Thumbi Ndung’u

Director for basic and translational science, Africa Health Research Institute (AHRI)
Professor Thumbi Ndung'u is an eminent HIV scientist who has made important contributions in the field of HIV vaccine and pathogenesis research. His research programme at AHRI is focussed on understanding how HIV and TB persist and replicate in the face of a hostile host immune system – with the goal of aiding the design of a safe, affordable and effective HIV-1 vaccine or effective immune-based therapies. Thumbi has a special interest in capacity building for biomedical research in Africa, primarily through the Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE) programme, based at AHRI. He is a Max Planck Society Group Leader and holds a professorship at the University of KwaZulu-Natal.

He is interested in understanding antiviral immune mechanisms and viral adaptation in HIV-1 subtype C infection as a pathway to vaccine development. His work has focussed on understudied populations and viral strains in resource-limited, high burden settings where knowledge of the role of antiviral immune responses, viral strains and associated genetic factors is likely to yield the greatest impact in terms of biomedical interventions like vaccines. Thumbi’s early work addressed the lack of biological tools for HIV vaccine and pathogenesis research on HIV-1 subtype C, the predominant subtype globally and in southern Africa. He generated and characterised the first infectious molecular of HIV-1 subtype C from primary isolates, and constructed the first infectious subtype C envelope-derived simian-human immunodeficiency virus able to replicate in rhesus macaque peripheral blood mononuclear cells. These tools were deposited in the NIH AIDS reagent program and remain available to researchers. The tools have facilitated in vitro and animal model studies of HIV-1 subtype C biology and vaccine development research.

Economy

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Asian Stocks Rally on AI Spending Optimism as Middle East Tensions Push Oil to Six-Week High

Asian stock markets advanced on Thursday as strong artificial intelligence (AI) investment plans from major U.S. technology companies boosted confidence in the regions semiconductor sector, while escalating conflict in the...

Australia Jobs Surge in June Strengthens Case for More RBA Rate Hikes

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Oil Prices Rise as Houthi Attacks on Saudi Tankers Heighten Middle East Supply Fears

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South Korea Q2 GDP Beats Forecasts as AI Chip Exports Drive Growth

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Politics

Arizona Primaries Set High-Stakes Governor and House Battles Ahead of Midterm Elections

Arizonas Republican primary delivered major victories for candidates backed by U.S. President Donald Trump, setting up closely watched contests for governor and a key U.S. House seat in the November 3 midterm elections....

Amish Shah Wins Arizona Democratic Primary in Key U.S. House Race

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Trump Administration Opens Civil Rights Probes Into Five U.S. Medical Schools Over Admissions

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ASEAN Forum Puts Middle East Conflict, South China Sea Tensions in Spotlight

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Science

Blue Origin New Glenn Explosion Could Delay Launch Operations Until 2028

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Trump Administration Releases New UFO Files and Apollo Mission Records

The U.S. Defense Department has released dozens of previously classified UFO-related files following an order from President Donald Trump, sparking renewed debate over unidentified anomalous phenomena (UAP) and government...

China vs. NASA: The New Moon Race and What's at Stake by 2030

The space race is back and this time, its a direct competition between the United States and China for dominance on the lunar surface. NASAs Artemis II mission recently made history when four astronauts flew farther into...

Technology

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OpenAI Australia Data Center Switches Cooling Strategy After Recycled Water Plan Fails

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