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Lizzy Ostler

Head of Chemistry, University of Brighton
My research is focused on the chemical analysis of, and intervention in, ageing processes. Building on postdoctoral experience in mechanistic enzymology (where I discovered the first catalytic antibody lactamase generated in response to a synthetic compound), I developed the first mathematical model to explain why some, but not all, tissues in Werner’s Syndrome patients show a premature degenerative phenotype. My work has since progressed to using experimental models to investigate putative causal mechanisms of ageing. My EPSRC/BBSRC SPARC funded project resulted in the first demonstration that age-related chemical changes in Drosophila are consistent with the “Green Theory” of ageing. More, recently we demonstrated that the highly-publicised postulated anti-ageing compound, Resveratrol, causes premature cellular senescence in primary cells in vitro. My latest research includes the development of a simple synthesis of novel “Resveralogues”. We are now evaluating our panel of over 40 compounds, in collaboration with multiple international laboratories, to determine the chemical features underlying the beneficial activities of stilbene molecules whilst abrogating the detrimental ones. The structure-activity relationships (SAR) we have developed are now informing our second generation compound designs.

Advances in anti-ageing research: how chemistry could hold the key to better health

Oct 29, 2019 19:37 pm UTC| Insights & Views Science Health

Given the opportunity to live much longer lives, many of us might feel less than thrilled at the prospect. After all, you might think, who would want to live an extra 20 years dealing with arthritis, dementia or heart...

Economy

World Bank Approves $1.1 Billion Emergency Funding for Bangladesh Amid Food and Energy Price Pressures

The World Bank has approved $1.1 billion in emergency financing for Bangladesh to help the country cope with the economic impact of rising food, fuel, and fertilizer prices driven by the ongoing conflict in the Middle...

Trump Threatens 100% Tariffs on Countries Imposing Digital Services Taxes on U.S. Tech Firms

U.S. President Donald Trump announced on Friday that the United States will impose a 100% tariff on imports from any country that enforces digital services taxes (DSTs) on American technology companies, significantly...

US Dollar Slips After PCE Inflation Data as Fed Rate Hike Expectations Stay Elevated

The U.S. dollar edged lower on Friday, extending its decline for a second consecutive session after a six-day winning streak pushed the greenback to its strongest level since May 2025. Despite the modest pullback, the...

Gold Price Ends Lower for Fourth Week Despite Rebound as Fed Rate Hike Bets Strengthen

Gold prices rebounded more than 1% on Friday but still finished the week in negative territory, as renewed expectations of Federal Reserve interest rate hikes and a stronger U.S. dollar continued to pressure the precious...

Wall Street Ends Lower as AI Stocks Drag Markets, Fed Rate Outlook Shifts

Wall Street closed slightly lower on Friday, capping a difficult week for U.S. equities as technology stocks led the decline. With geopolitical tensions easing following diplomatic progress in the Middle East and oil...

Politics

US, Iran Agree to Halt Attacks Ahead of Doha Talks on Strait of Hormuz

The United States and Iran have reportedly agreed to halt military attacks as both sides prepare for high-level talks in Doha on Tuesday aimed at resolving tensions over the Strait of Hormuz, according to a senior U.S....

Russian Attacks Kill Four in Ukraine as Zaporizhzhia and Kharkiv Come Under Fire

Russian attacks across southeastern and northeastern Ukraine killed at least four people and left dozens injured on Sunday, according to regional officials, as fighting between Kyiv and Moscow continued with no sign of...

Ukraine Strikes Russian Titan-Barrikady Plant With Long-Range FP-5 Flamingo Missile

Ukraine said it carried out a long-range missile strike on a major Russian military production facility in the Volgograd region overnight, marking another escalation in Kyivs campaign to target defense infrastructure deep...

Javier Milei Cabinet Chief Manuel Adorni Resigns Amid Spending Scandal Investigation

Argentine President Javier Milei has suffered a political setback after Cabinet Chief Manuel Adorni resigned following mounting scrutiny over his finances and personal spending, triggering fresh pressure on the government...

Australia Plans Higher Fines for Social Media Firms Failing to Block Underage Users

Australia is moving to strengthen its landmark online safety law by proposing significantly tougher penalties for social media companies that fail to prevent children under 16 from accessing their platforms. The planned...

Science

Blue Origin New Glenn Explosion Could Delay Launch Operations Until 2028

Blue Origin is facing a significant setback after a dramatic explosion involving its New Glenn rocket severely damaged a launch pad at Cape Canaveral, Florida. According to NASA Administrator Jared Isaacman, repairs to the...

Blue Origin New Glenn Rocket Explodes During Launch Pad Test, Delaying Space Ambitions

Blue Origin suffered a major setback after its uncrewed New Glenn rocket exploded during a launch pad test in Florida on Thursday, raising new challenges for Jeff Bezos space company as it competes with Elon Musks SpaceX...

SpaceX Delays Starship V3 Launch Ahead of Potential Record IPO

SpaceX on Thursday postponed the highly anticipated launch of its 12th Starship rocket test from Texas after technical issues interrupted the final countdown. The company now plans to attempt the Starship V3 launch again...

Trump Administration Releases New UFO Files and Apollo Mission Records

The U.S. Defense Department has released dozens of previously classified UFO-related files following an order from President Donald Trump, sparking renewed debate over unidentified anomalous phenomena (UAP) and government...

China vs. NASA: The New Moon Race and What's at Stake by 2030

The space race is back and this time, its a direct competition between the United States and China for dominance on the lunar surface. NASAs Artemis II mission recently made history when four astronauts flew farther into...

Technology

Italy Investigates Microsoft Over Microsoft 365 AI Subscription Price Hike

Italys antitrust authority has launched an investigation into Microsoft over allegations of unfair commercial practices tied to the pricing changes for its Microsoft 365 subscription service. The probe focuses on whether...

US Seizes Nearly 400 Illegal World Cup Streaming Domains in Global Anti-Piracy Crackdown

U.S. authorities have seized nearly 400 internet domains that were allegedly used to illegally stream FIFA World Cup matches, marking one of the largest anti-piracy enforcement actions tied to the global soccer tournament....

SpaceX, Charter Communications Explore Mobile Partnership to Expand Starlink Wireless Service

SpaceX and Charter Communications are reportedly in executive-level discussions about forming a strategic partnership that could accelerate the expansion of consumer mobile services across the United States. According to a...

OpenAI IPO Delay Weighs on SoftBank Shares as AI Valuation Concerns Grow

SoftBank Group (TYO:9984) shares tumbled sharply on Friday after a report suggested that OpenAI is considering postponing its highly anticipated initial public offering (IPO), delaying what many investors had expected to...

Apple Supplier Stocks Slide as Samsung, SK Hynix Lead Selloff After Apple Price Hikes

Apples major Asian suppliers came under heavy selling pressure on Friday after the iPhone maker announced significant price increases for its MacBook and iPad lineup, fueling concerns that rising semiconductor costs are...