Associate Professor of Biological Sciences, University of Maryland, Baltimore County
My research interests lie primarily in the evolution of transcriptional regulatory networks in Bacteria, specifically on the co-evolution of transcription factors, their cognate binding sites and the regulatory networks they spawn to fulfill complex regulatory programs involved in key pathogenic processes, such as the transfer of antiobiotic resistance determinants or the creation of biofilms. My lab uses evolutionary simulations, biophysical and dynamic models, systems biology and comparative genomics approaches to probe into the evolution of transcriptional regulatory networks. My lab also works on the creation of community-oriented services for the annotation of scientific data, such as the CollecTF database (www.collectf.org) dedicated to compiling data on transcription factor-binding sites across the Bacteria domain. This work involves the design and development of biological databases, working in close collaboration with ontology development groups and core development teams at large biomedical data repositories, such as the NCBI and the EMBL-EBI.
Imagine a world where your odds of surviving minor surgery were one to three. A world in which a visit to the dentist could spell disaster. This is the world into which your great-grandmother was born. And if humanity...