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Diwakar Davar

Assistant Professor of Medicine, University of Pittsburgh

My research interests lies in translational cancer immunotherapy and early-phase clinical trials. I am working with Dr. Zarour and Kirkwood to coordinate the clinical care and translational research of a novel trial combining PD-1 inhibitor Pembrolizumab with immunomodulatory PEG-IFN. I presented preliminary results at ASCO 2015. Final results have been collated along with correlative analyses and are pending publication.

More recently, in collaboration with Bristol-Myers Squibb and based on published findings by Dr Zarour’s laboratory, I have contributed to the development and implementation of a first-in-human study of TIGIT mAb (BMS-986207) singly and in combination with Nivolumab that is presently in active accrual and for which I am the institutional Principle Investigator. I am also the institutional Principle Investigator for first-in-human studies of GITR mAb (TRX-518), pegylated arginase (AEB1102) and IDO inhibitor (BMS-986205).

Based on emerging data implicating intestinal dysbiosis in mediating non-response to PD-1 blockade, I developed with Dr. Zarour a protocol evaluating fecal microbiota transplant in combination with PD-1 blockade to treat PD-1 non-responders. This first-in-human study was selected for funding by Merck to support the clinical costs and is IRB approved. In the context of this trial that I am the Principle Investigator for, I work in close collaboration with Dr. Zarour and co-investigators Drs. Methe and Benos, for the performance of the correlative studies in the context of the new clinical trial with fecal transplant microbiota and pembrolizumab in PD-1 refractory melanoma patients.
Clinical Interest

Could your gut microbes hinder your cancer treatment? A new first-in-human trial investigates

Aug 01, 2018 15:23 pm UTC| Insights & Views Health

Could the poop of some cancer patients hold the key to treating certain cancers in all people? What does cancer have to do with poop? In the past few years, researchers around the world, including us, have realized that...

Economy

Gold Prices Edge Higher as Markets Await Key U.S. PCE Inflation Data

Gold prices moved higher in Asian trading on Friday, supported by a weakening U.S. dollar and strong expectations that the Federal Reserve will cut interest rates at its upcoming December 910 meeting. Spot gold rose 0.5%...

Asia’s IPO Market Set for Strong Growth as China and India Drive Investor Diversification

Asias equity capital markets are poised for another strong year as a surge of high-profile IPOs from China and India attracts global investors seeking diversification beyond U.S. assets. In 2025, Asian ECM...

Spain’s Industrial Output Records Steady Growth in October Amid Revised September Figures

Spains industrial sector posted a moderate yet encouraging rise in October, with industrial output increasing 1.2% compared to the same month last year, according to new data released by the National Statistics Institute...

European Stocks Rise as Markets Await Key U.S. Inflation Data

European stock markets edged higher on Friday as investors looked ahead to the delayed release of the Federal Reserves preferred inflation metric, a key indicator ahead of next weeks policy meeting. By early European...

European Oil & Gas Stocks Face 2026 With Cautious Outlook Amid Valuation Pressure

European oil and gas equities are entering 2026 on a more cautious footing as J.P. Morgans latest EU Oils Outlook highlights tightening valuations and growing concerns over a projected global oil oversupply. Despite Brent...

Politics

Taiwan Opposition Criticizes Plan to Block Chinese App Rednote Over Security Concerns

Taiwans political landscape heated up after the government announced a plan to suspend access to the Chinese social media platform Rednoteknown as Xiaohongshufor one year. The interior ministry said the proposed ban stems...

China’s Expanding Maritime Military Presence Alarms Taiwan and Japan

Taiwan and Japan expressed growing concern on Friday over Chinas expanding military activity across East Asian waters, following a Reuters report revealing Beijings largest maritime deployment to date. According to...

Honduras Election Turmoil Intensifies as Nasralla Blames Trump for Shift in Results

Honduran presidential candidate Salvador Nasralla says last-minute interference by former U.S. President Donald Trump undermined his chances in the countrys tightly contested election. Speaking with Reuters, Nasralla, a...

Australia and Japan Strengthen Defence Cooperation Amid Rising Regional Tensions

Australian Defence Minister Richard Marles will travel to Japan on Saturday for high-level defence talks with his counterpart, Shinjiro Koizumi, as both nations deepen security cooperation in response to growing regional...

U.S. Justice Department Orders Intensified Probe Into Antifa and Domestic Extremist Groups

U.S. Attorney General Pam Bondi has directed federal law enforcement agencies to significantly ramp up investigations into the antifa movement and other groups deemed potential domestic extremist threats, according to an...

Science

Senate Sets December 8 Vote on Trump’s NASA Nominee Jared Isaacman

The U.S. Senate Commerce Committee announced it will vote on December 8 on President Donald Trumps renewed nomination of private astronaut and tech entrepreneur Jared Isaacman to lead NASA. Isaacman, known for his...

NASA Cuts Boeing Starliner Missions as SpaceX Pulls Ahead

NASA has significantly scaled back Boeings Starliner program after years of technical issues and delays, announcing that the next Starliner mission to the International Space Station (ISS) will fly without astronauts. The...

Blue Origin’s New Glenn Achieves Breakthrough Success With First NASA Mission

Blue Origins massive New Glenn rocket marked a major milestone as it completed its first mission for paying customers, sending two NASA satellites toward Mars and successfully landing its reusable booster at sea. The...

Cogent Biosciences Soars 120% on Breakthrough Phase 3 Results for Bezuclastinib in GIST Treatment

Cogent Biosciences (NASDAQ: COGT) shares skyrocketed over 120% after the biotech company announced groundbreaking results from its Phase 3 PEAK trial evaluating bezuclastinib in combination with sunitinib for patients with...

Trump and Merck KGaA Partner to Slash IVF Drug Costs and Expand Fertility Coverage

U.S. President Donald Trump and German pharmaceutical company Merck KGaA have announced a groundbreaking deal aimed at lowering the cost of in-vitro fertilization (IVF) treatments while boosting access to fertility care in...

Technology

EU Prepares Antitrust Probe Into Meta’s AI Integration on WhatsApp

The European Commission is reportedly preparing to launch a new antitrust investigation into Meta Platforms Inc. (NASDAQ: META) over the companys recent rollout of artificial intelligence features within WhatsApp....

Sam Altman Reportedly Explored Funding for Rocket Venture in Potential Challenge to SpaceX

OpenAI CEO Sam Altman reportedly explored raising significant capital to acquire or partner with a rocket company, a move that could have created direct competition with Elon Musks SpaceX. According to a report from the...

Wikipedia Pushes for AI Licensing Deals as Jimmy Wales Calls for Fair Compensation

Wikipedia is seeking additional licensing deals with major technology companies to address the growing financial burden caused by artificial intelligence firms heavily scraping its platform, according to co-founder Jimmy...

Firelight Launches as First XRP Staking Platform on Flare, Introduces DeFi Cover Feature

Firelight reaches 25M XRP deposit cap within hours of launch; ushers in a new era for decentralized XRP staking. A new XRP staking platform, Firelight, has officially launched on the Flare blockchain, marking the first...

OpenAI Moves to Acquire Neptune as It Expands AI Training Capabilities

OpenAI has confirmed plans to acquire Neptune, a startup known for its advanced tools that help companies track, monitor, and optimize AI model training workflows. Although the company did not release the financial details...