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Fri, Sep 25, 2026 08:33 PM All times are UTC

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Frances Spragge

We are only just beginning to understand the dense and diverse microbial communities that live in and on us. A key benefit of the microbiome is its ability to provide protection against pathogens, known as colonisation resistance. Resident strains of bacteria compete with incoming pathogens and help prevent them from colonising and causing infection. In my DPhil, I am investigating the ecological interactions between symbiont strains and pathogens in order to further our understanding of colonisation resistance. My research focuses on the gut microbiome and I use the species Klebsiella pneumoniae as a model pathogen. K. pneumoniae can colonise the gastrointestinal tract of healthy individuals, where it does not usually cause disease, but acts as a reservoir for opportunistic infection of other parts of the body such as the lungs and urinary tract. It is an important nosocomial pathogen that, due to the widespread emergence of antibiotic-resistant strains, poses an increasing threat to human health. Probiotics that engineer the gut community to resist K. pneumoniae colonisation have potential as an alternative to antibiotics. After initially screening 100 human gut symbionts for their individual ability to inhibit K. pneumoniae, I tested combinations of up to 50 species to find out how species diversity influences community performance. My research investigates whether K. pneumoniae inhibition is due simply to the additive effect of member strains, or if the combination of strains also plays a role, implying an effect of interactions between symbiont strains. My lab work takes place in the Department of Biochemistry and in the germ-free mouse facility at the Kennedy Institute of Rheumatology.

Diverse gut microbiomes give better protection against harmful bugs - now we know why

Dec 18, 2023 02:19 am UTC| Health

In the last decade, it has become increasingly clear that a gut full of friendly microbes (the microbiome) is vital for our good health. It has also become clear that a healthy microbiome is one with a diverse population...

Economy

Oil Prices Fall on U.S.-Iran Hormuz Deal Hopes

Oil prices fell on Friday, ending a two-day rally as traders weighed reports that the United States and Iran were discussing a phased agreement that could eventually reopen the Strait of Hormuz and ease disruptions to...

Canadian Dollar Faces Pressure as Fed-BoC Policy Gap Widens

The Canadian dollar could remain under pressure through the end of 2026 as diverging monetary policy between the Federal Reserve and Bank of Canada weighs on the currency, according to CIBC Capital Markets. CIBC expects...

Japanese Yen Rebounds as Trump Flags Currency Weakness

The Japanese yen ended a five-day losing streak on Friday, rebounding from the closely watched 160-per-dollar level after Tokyo disclosed that U.S. President Donald Trump had raised concerns about the currencys weakness...

US Comfortable With Canada Trade Standoff as Import Bans Loom

President Donald Trumps administration is prepared to maintain its escalating trade dispute with Canada as new import restrictions approach and Washington threatens additional tariffs on key Canadian industries. U.S. Trade...

Dollar Falls as Oil Eases, Yen Jumps on Intervention Signals

The U.S. dollar weakened on Friday as oil prices retreated, although the currency remained headed for a second consecutive weekly gain as expectations for another Federal Reserve rate hike increased. The Japanese yen,...

Politics

Colombia Extradites FARC Dissident Leader ‘Spider’ to US

Colombia has extradited Geovany Andres Rojas, a senior commander of a dissident faction linked to the former FARC rebel movement, to the United States, where he is wanted on drug-trafficking charges. Rojas, widely known by...

Evan Gershkovich Says FSB Set Trap for 2023 Russia Arrest

Wall Street Journal reporter Evan Gershkovich says Russias Federal Security Service orchestrated an elaborate sting operation that led to his 2023 arrest on espionage charges, according to his first detailed published...

Saudi Arabia Seeks Military Support as Houthi Attacks Escalate

Saudi, Turkish and Pakistani military chiefs were expected to discuss support for Saudi Arabia as escalating Houthi attacks intensify security concerns across the Middle East, while new restrictions on Iranian flights add...

Putin Says Ukraine Peace Proposals Remain on Table

Russian President Vladimir Putin said Friday that proposals aimed at ending the 4-1/2-year war in Ukraine remain under consideration, although Moscow must determine which options best serve Russias interests. Speaking to...

Iran Rejects Nuclear Concessions in Hormuz Deal

Iran will not compromise on its nuclear rights even if the United States accepts Tehrans proposal for reopening the Strait of Hormuz, according to a senior Iranian official, underscoring major obstacles to ending the...

Science

Blue Origin New Glenn Explosion Could Delay Launch Operations Until 2028

Blue Origin is facing a significant setback after a dramatic explosion involving its New Glenn rocket severely damaged a launch pad at Cape Canaveral, Florida. According to NASA Administrator Jared Isaacman, repairs to the...

Blue Origin New Glenn Rocket Explodes During Launch Pad Test, Delaying Space Ambitions

Blue Origin suffered a major setback after its uncrewed New Glenn rocket exploded during a launch pad test in Florida on Thursday, raising new challenges for Jeff Bezos space company as it competes with Elon Musks SpaceX...

SpaceX Delays Starship V3 Launch Ahead of Potential Record IPO

SpaceX on Thursday postponed the highly anticipated launch of its 12th Starship rocket test from Texas after technical issues interrupted the final countdown. The company now plans to attempt the Starship V3 launch again...

Trump Administration Releases New UFO Files and Apollo Mission Records

The U.S. Defense Department has released dozens of previously classified UFO-related files following an order from President Donald Trump, sparking renewed debate over unidentified anomalous phenomena (UAP) and government...

China vs. NASA: The New Moon Race and What's at Stake by 2030

The space race is back and this time, its a direct competition between the United States and China for dominance on the lunar surface. NASAs Artemis II mission recently made history when four astronauts flew farther into...

Technology

AMD Hits $1 Trillion as BofA Raises Price Target to $720

Advanced Micro Devices (NASDAQ: AMD) has joined the $1 trillion market capitalization club, and BofA Securities believes the semiconductor giant has room to climb further as artificial intelligence drives stronger demand...

US Appeals Court Upholds Anthropic AI Supply Chain Ban

A U.S. federal appeals court has upheld the Department of Wars decision to exclude Anthropic from its supply chain, handing the Trump administration a significant victory in a closely watched dispute over military use of...

Solidigm Eyes $150 Billion IPO as SK Hynix Expands AI Storage Push

SK Hynix subsidiary Solidigm is considering a U.S. initial public offering as early as next year that could value the semiconductor storage company at as much as $150 billion, according to a Reuters report on Friday. The...

Meta Found Liable in New Mexico Facebook Data Privacy Case

A New Mexico jury has found Meta Platforms liable for misleading consumers about Facebook user privacy and data-sharing practices in a case tied to the Cambridge Analytica scandal. The verdict followed a two-week trial in...

DaVoice Sues Perplexity AI Over Trade Secrets

AI technology startup DaVoice has filed a lawsuit against Perplexity AI in California federal court, accusing the artificial intelligence company of misappropriating trade secrets connected to wake word technology used in...