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John Greenman

Professor of Tumour Immunology, University of Hull
Prof Greenman is Professor of Tumour Immunology at the University of Hull and Scientific Director of the Daisy Laboratories.

Coming from an immunology background Prof Greenman is extremely interested in understanding how the immune system is often subverted during carcinogenesis, and more importantly how such knowledge can be used clinically (diagnostically, prognostically or therapeutically). A novel way to combine investigations of both tumour biology and the anti-tumour response is with the advent of an innovative, microfluidic model system for handling tumour tissue that has been developed in collaboration with colleagues in Chemistry. This technology is allowing studies of specific cellular and molecular interactions in real-time in a tissue biopsy, rather than using disaggregated cells.

A second, related, research group focuses on the Immunobiology of Head & Neck Cancer. This unit benefits from the excellent links that have been forged with the surgical unit in Hull, and is based in the Daisy laboratories at Castle Hill Hospital (Hull & East Yorkshire NHS Trust). The aim is to characterise the systemic and intra-tumoural cytokine repertoires together with the enumeration and functional assessment of T regulatory cells; and then correlate these biological parameters with clinical outcome.

Proteins wear clothes – and understanding their fashion choices could help us treat cancer

Oct 17, 2018 22:21 pm UTC| Insights & Views Health

We humans are top of the evolutionary tree, the most complex organisms that have ever lived on Earth in five billion years. Right? One way we might actually prove our biological complexity is to look at the number of...

Economy

The US is one of the least trade-oriented countries in the world – despite laying the groundwork for today’s globalized system

Given the spate of news about international trade lately, Americans might be surprised to learn that the U.S. isnt very dependent on it. Indeed, looking at trade as a percentage of gross domestic product a metric...

Beyond the spin, beyond the handouts, here’s how to get a handle on what’s really happening on budget night

Three weeks from now, some of us will be presented with a mountain of budget papers, and just about all of us will get to hear about them on radio, TV or news websites on budget night. The quickest way to find out what...

Johannesburg in a time of darkness: Ivan Vladislavić’s new memoir reminds us of the city’s fragility

Ivan Vladislavić is Johannesburgs literary linkman. He tells us, in the first pages of his new book, The Near North, that before cities were lit, first by gaslight and later electricity, people of means paid torchbearers...

Economist Chris Richardson on an ‘ugly’ inflation result and the coming budget

With Jim Chalmerss third budget on May 14, Australians will be looking for some more cost-of-living relief beyond the tax cuts although they have been warned extra measures will be modest. As this weeks consumer price...

Inflation is slowly falling, while student debt is climbing: 6 graphs that explain today’s CPI

Australias inflation rate has fallen for the fifth successive quarter, and its now less than half of what it was back in late 2022. The annual rate peaked at 7.8% in the December quarter of 2022 and is now just 3.6%, in...

Politics

US Urges China, Russia to Reject AI Control in Nuclear Arms, Align with Global Norms

Paul Dean, a senior U.S. arms control official, emphasized the critical need for China and Russia to join the U.S. in declaring that humans will always decide on the deployment of nuclear weapons, not artificial...

South Africa’s youth are a generation lost under democracy – study

South African president Cyril Ramaphosa recently painted a rosy picture in which the countrys youth democracys children had enormous opportunities for advancement, all thanks to successive post-apartheid governments led...

Sadiq Khan on track for third term as London mayor – but nearly half of Londoners dissatisfied with performance

Polls have consistently shown that the incumbent mayor of London, Sadiq Khan, appears to be on track to win a third term in office at the upcoming mayoral elections on May 2. One poll we commissioned as part of our...

Biden administration tells employers to stop shackling workers with ‘noncompete agreements’

Most American workers are hired at will: Employers owe their employees nothing in the relationship except earned wages, and employees are at liberty to quit at their option. As the rule is generally stated, either party...

Labour can afford to be far more ambitious with its economic policies – voters are on board

To say that the Labour party is flying high in the polls is something of an understatement. But despite its consistent lead against the Tories, the opposition finds itself in a rather odd position: on the cusp of power but...

Science

IceCube researchers detect a rare type of energetic neutrino sent from powerful astronomical objects

About a trillion tiny particles called neutrinos pass through you every second. Created during the Big Bang, these relic neutrinos exist throughout the entire universe, but they cant harm you. In fact, only one of them is...

The Mars Sample Return mission has a shaky future, and NASA is calling on private companies for backup

A critical NASA mission in the search for life beyond Earth, Mars Sample Return, is in trouble. Its budget has ballooned from US$5 billion to over $11 billion, and the sample return date may slip from the end of this...

A Nasa rover has reached a promising place to search for fossilised life on Mars

While we go about our daily lives on Earth, a nuclear-powered robot the size of a small car is trundling around Mars looking for fossils. Unlike its predecessor Curiosity, Nasas Perseverance rover is explicitly intended to...

The rising flood of space junk is a risk to us on Earth – and governments are on the hook

A piece of space junk recently crashed through the roof and floor of a mans home in Florida. Nasa later confirmed that the object had come from unwanted hardware released from the international space station. The 700g,...

Peter Higgs was one of the greats of particle physics. He transformed what we know about the building blocks of the universe

Peter Higgs, who gave his name to the subatomic particle known as the Higgs boson, has died aged 94. He was always a modest man, especially when considering that he was one of the greats of particle physics the area of...

Technology

Bitfinex CTO Deems Database Breach Claims 'Fake' Amidst Hacker Allegations

Bitfinexs Chief Technology Officer Paolo Ardoino has cast doubts on claims of a database breach by hacker organization FSOCIETY, branding the allegations as fake. Ardoino refuted the purported leak of 22,500 user emails...

Bitcoin's Next Bull Run Hinges on Key Trading Pattern Confirmation: Analysts

Cryptocurrency traders are eyeing a potential bullish reversal for Bitcoin, with analysts suggesting that validating an inverse head and shoulders pattern could propel the next leg up for the leading cryptocurrency....

Walmart Spotted with Tesla Semi in California as True Launch Date Revealed

Walmarts adoption of a Tesla Semi hit the California highways, signaling the electric trucks expanding reach. The sighting follows Teslas revelation of a late 2025 and early 2026 launch window for the highly anticipated...

Tesla Cybertruck 'Odyssey' Roars into Europe, Berlin Display Kicks Off Tour

Teslas futuristic Cybertruck made a striking debut at Berlins Mall of Berlin, marking the launch of its European tour. The event, part of the Cyber Odyssey, precedes the electric pickups journey through 24 cities as Tesla...

Altcoin Market Rally Predicted, Analysts Forecast $4 Trillion Market Cap Surge

Analysts are predicting a substantial rally in the altcoin market, with projections indicating a surge that could drive the market cap to an impressive $4 trillion. This optimistic outlook is supported by positive economic...