Toyota Retains Global Auto Sales Crown in 2025 With Record 11.3 Million Vehicles Sold 
Boeing Secures New Labor Contract With Former Spirit AeroSystems Employees 
Bob Iger Plans Early Exit as Disney Board Prepares CEO Succession Vote 
SpaceX Updates Starlink Privacy Policy to Allow AI Training as xAI Merger Talks and IPO Loom 
Chinalco and Rio Tinto Acquire Controlling Stake in Brazil’s CBA for $903 Million 
Samsung Electronics Posts Record Q4 2025 Profit as AI Chip Demand Soars 
SpaceX Reports $8 Billion Profit as IPO Plans and Starlink Growth Fuel Valuation Buzz 
Trump Threatens Aircraft Tariffs as U.S.-Canada Jet Certification Dispute Escalates 
Amazon Stock Dips as Reports Link Company to Potential $50B OpenAI Investment 
American Airlines Plans Return to Venezuela Flights After U.S. Lifts Ban 
NVIDIA, Microsoft, and Amazon Eye Massive OpenAI Investment Amid $100B Funding Push 
Panama Supreme Court Voids Hong Kong Firm’s Panama Canal Port Contracts Over Constitutional Violations 
US Judge Rejects $2.36B Penalty Bid Against Google in Privacy Data Case 
Microsoft AI Spending Surge Sparks Investor Jitters Despite Solid Azure Growth 
Climate Adaptation at Home: How Irrigreen Makes Conservation Effortless 
Saks Global to End Saks on Amazon Partnership Amid Bankruptcy Restructuring 
MIDLOTHIAN, Va., May 25, 2017 -- Ammonett Pharma LLC (the Company or Ammonett), a privately-held biotechnology company developing a novel, daily, orally-administered mini-pill Growth Hormone (GH) secretagogue (Oratrope), today announced that it has received a Notice of Allowance from the U.S. Patent and Trademark Office for Patent Application No: 15/271,542, entitled “DETECTING AND TREATING GROWTH HORMONE DEFICIENCY”. This is a patent that claims a method of treating children who will respond to Oratrope, the Company’s lead product candidate initially targeting Pediatric Growth Hormone Deficiency (PGHD), in an equivalent manner to those treated with injectable recombinant Growth Hormone (rhGH).
PGHD in children and Growth Hormone Deficiency (GHD) in adults are conditions caused by insufficient amounts of GH in the body. Children with GHD have abnormally short stature with normal body proportions. GHD can be present at birth (congenital) or develop later (acquired). Current standard treatment of PGHD and GHD is through daily injections of rhGH.
Oratrope is Ammonett’s novel drug, ibutamoren, a small molecule, which mimics the effects of Growth Hormone release inducing hormone (Ghrelin), a natural hormone found in the stomach, which controls the release of GH from the pituitary gland. Oratrope is intended to be administered orally as a daily mini-pill, allowing the body to produce its own natural GH in a physiologically pulsatile manner over 24 hours, unlike the single daily bolus of exogenous GH delivered at present by injection.
“This patent allowance is another important achievement for Ammonett, adding key intellectual property protection in GHD, and complementing our current patent estate in Sarcopenia,” said Michael Thorner, MB, BS, DSc, FRCP, MACP, Ammonett’s Founder and Chief Scientific Officer. “We believe the use of Oratrope to quickly detect GHD through a simple blood draw following the oral administration in a mini-pill formulation will allow for more accurate diagnosis of GHD and enable Ammonett to identify which patients will respond to Oratrope in a manner similar to injected rhGH, which, based on our discussions with key opinion leaders in the industry, represents approximately 70% of the PGHD market. We look forward to initiating our planned Phase 2b trial in the PGHD indication.”
About Ammonett Pharma LLC
Ammonett Pharma LLC, is a privately held biopharmaceutical company focused on the development of novel therapies restoring normal growth and metabolism. Oratrope is Ammonett’s lead product, targeting children with PGHD who have an intact hypothalamic pituitary GH axis.
Contacts Kevin P Tully CPA, CGA Chief Executive Officer [email protected] Or Andrew Amiel VP Business Development [email protected]
