Adaptimmune Announces an Oral Presentation and Four Trials in Progress Posters at the American Society of Clinical Oncology (ASCO) Annual Meeting

PHILADELPHIA and OXFORD, United Kingdom, May 26, 2017 -- Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in T-cell therapy to treat cancer, today announced an oral presentation, as well as four trials in progress posters, at the 2017 ASCO annual meeting in Chicago, Illinois on June 2 through June 6, 2017.

During an oral presentation scheduled for 1:15-1:27 PM CDT on June 5^th, Dr. Sandra P. D’Angelo of the Memorial Sloan Kettering Cancer Center will present a full update on Cohorts 1, 2, 3, and 4 from Adaptimmune’s ongoing study of NY-ESO SPEAR T-cells in patients with synovial sarcoma.

The Company will host a webinar / teleconference on June 6^th from 8:00–9:00 AM EDT (1:00 -2:00 PM BST) to discuss the updated synovial sarcoma clinical data. Call in details and the webinar link will be made available in the Investors section of Adaptimmune’s website (http://www.adaptimmune.com).

The four trials in progress posters will summarize the study designs for Adaptimmune’s ongoing NY‑ESO trials in myxoid/round cell liposarcoma (MRCLS), ovarian cancer, and non-small cell lung cancer (NSCLC); the Company’s ongoing MAGE-A10 trial in NSCLC, and its MAGE-A10 triple tumor study in patients with head and neck, melanoma, or urothelial “bladder” tumors.

Adaptimmune will also host a corporate exhibition booth in the Oncology Professionals Hall (Booth #5031).

Details regarding the oral presentation and the four trials in progress posters are as follows:

Oral Presentation:
Monday, June 5, 2017
Session: Developmental Therapeutics—Immunotherapy

• Abstract ID: 3000
 — Title: “Open label, non-randomized, multi-cohort pilot study of genetically engineered NY-ESO-1 specific NY-ESO-1^c259t in HLA-A2⁺ patients with synovial sarcoma (NCT01343043)”
 — Presentation Time: 1:15-1:27 PM CDT
 — Location:  Hall D1

Trials in Progress Posters:
Monday, June 5, 2017
Session: Developmental Therapeutics—Immunotherapy
Presentation Time: 8:00-11:30 AM CDT
Location:  Hall A

• Abstract ID: TPS3094
 — Poster Board #: 187b
  — Title: “A phase I/IIa, open-label, clinical trial evaluating the safety and efficacy of autologous T-cells expressing enhanced T-cell receptors (TCRs) specific for NY-ESO-1 in patients with recurrent or treatment refractory ovarian cancer (NCT01567891)”

 
• Abstract ID: TPS3097
 — Poster Board #: 189a 
 — Title: “A pilot study of NY-ESO-1^c259 T-cells in subjects with advanced myxoid/round cell liposarcoma (NCT02992743)”


• Abstract ID: TPS3096
 — Poster Board #: 188b
 — Title: “Two phase I/II open-label clinical trials evaluating the safety and efficacy of autologous T‑cells expressing enhanced TCRs specific for NY-ESO-1 or MAGE-A10 in subjects with stage IIIb or stage IV non-small cell lung cancer (NCT02588612/NCT02592577)”

• Abstract ID: TPS3098
— Poster Board #: 189b
  — Title: “A phase I single-arm, open-label clinical trial evaluating safety of MAGE-A10^c796T in subjects with advanced or metastatic head and neck, melanoma, or urothelial tumors (NCT02989064)”

About Adaptimmune
Adaptimmune is a clinical-stage biopharmaceutical company focused on the development of novel cancer immunotherapy products. The Company’s unique SPEAR (Specific Peptide Enhanced Affinity Receptor) T-cell platform enables the engineering of T-cells to target and destroy cancer, including solid tumors. Adaptimmune has a number of proprietary clinical programs, and is also developing its NY-ESO SPEAR T-cell program under a strategic collaboration and licensing agreement with GlaxoSmithKline. The Company is located in Philadelphia, USA and Oxfordshire, U.K. For more information, please visit http://www.adaptimmune.com

Forward-Looking Statements
This release contains “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 (PSLRA). These forward-looking statements involve certain risks and uncertainties. Such risks and uncertainties could cause our actual results to differ materially from those indicated by such forward-looking statements, and include, without limitation: the success, cost and timing of our product development activities and clinical trials and our ability to successfully advance our TCR therapeutic candidates through the regulatory and commercialization processes. For a further description of the risks and uncertainties that could cause our actual results to differ materially from those expressed in these forward-looking statements, as well as risks relating to our business in general, we refer you to our Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on May 10, 2017, and our other SEC filings. The forward-looking statements contained in this press release speak only as of the date the statements were made and we do not undertake any obligation to update such forward-looking statements to reflect subsequent events or circumstances.

Adaptimmune Contacts
Investor Relations
Juli P. Miller, Ph.D. 
T: (215) 825-9310
E: [email protected]

Media Relations 
Margaret Henry
T: +44 (0)1235 430036
Cell: +44 (0)7710 304249
E: [email protected]