Menu

Search

  |   Health

Menu

  |   Health

Search

Schizophrenia may cause type 2 diabetes, new study finds

0
comments

People with schizophrenia tend to die up to 30 years earlier than the general population. Many of these untimely deaths are due to physical disorders, including heart attacks and stroke, for which diabetes is a major risk factor.

Antipsychotic drugs are known to increase the risk of type 2 diabetes, but there are other things that make schizophrenics particularly susceptible to the disorder, including poor diet and a lack of exercise. However, our latest study found that the risk of developing diabetes in people with schizophrenia remains high even when we take these factors into account.

People with long-term schizophrenia are three times more likely than the general population to have diabetes. The link between schizophrenia and diabetes was first made back in the 19th century. This was long before the use of antipsychotics, and in an era when diets were less likely to cause diabetes. This could suggest that there is a causative link between schizophrenia and diabetes.

Our study examined whether diabetes risk is already raised in people at the onset of schizophrenia – before they’ve started taking antipsychotic drugs or when they’ve only just started taking them.

We pooled data from multiple studies that examined evidence of diabetic risk in blood samples from people with early schizophrenia prescribed little or no antipsychotic medication. Diabetes is characterised by elevated blood glucose. The higher the level of glucose in the blood, the higher the risk of diabetes.

We demonstrated that compared with healthy individuals, people with schizophrenia had higher levels of glucose in the blood. We also looked at levels of insulin. Insulin is a hormone that triggers the movement of glucose from blood into tissue. Raised insulin levels are seen in type 2 diabetes. We demonstrated higher levels of insulin, and increased levels of insulin resistance in individuals with early schizophrenia.

Hints of a direct role of schizophrenia in diabetes

These results remained statistically significant even when we restricted our analysis to studies where people with schizophrenia were matched to healthy controls with regards their diet, the amount of exercise they engaged in and their ethnic background. This suggests that our results were not wholly driven by differences in lifestyle factors or ethnicity between the two groups, and may therefore point towards a direct role for schizophrenia in increasing risk of diabetes.

There are several factors that could increase the likelihood of developing both conditions. These include a shared genetic risk, as well as shared developmental risk factors. For example, premature birth and low birth weight are recognised as risk factors for the development of both schizophrenia and diabetes later in life. Raised levels of the stress hormone cortisol is also a risk factor for diabetes. It is possible that the stress associated with developing schizophrenia, which sees levels of cortisol rise, may also contribute to higher diabetic risk.

These findings are a wake-up call that we need to rethink the link between diabetes and schizophrenia and start prevention right from the onset of schizophrenia. It is a case of treating the mind and the body right from the start.

The ConversationToby Pillinger does not work for, consult, own shares in or receive funding from any company or organisation that would benefit from this article, and has disclosed no relevant affiliations beyond the academic appointment above.

This article was originally published on The Conversation. Read the original article.The Conversation

  • ET PRO
  • Market Data

Market-moving news and views, 24 hours a day >

January 20 07:00 UTC Released

DEProducer Prices YY

Actual

1.0 %

Forecast

1.0 %

Previous

0.1 %

January 20 07:00 UTC Released

DEProducer Prices MM

Actual

0.4 %

Forecast

0.4 %

Previous

0.3 %

January 23 07:00 UTC 399399m

TRConsumer Confidence*

Actual

Forecast

Previous

63.40

January 23 13:00 UTC 759759m

SACPI YY*

Actual

Forecast

Previous

2.3 %

January 23 13:00 UTC 759759m

SACPI MM*

Actual

Forecast

Previous

-0.2 %

January 23 13:30 UTC 789789m

CAWholesale Trade MM

Actual

Forecast

Previous

1.1 %

January 23 15:00 UTC 879879m

EZConsumer Confid. Flash

Actual

Forecast

Previous

-5.1 %

January 23 19:00 UTC 11191119m

ARAnnual Industrial Output*

Actual

Forecast

Previous

-2.5 %

January 23 21:00 UTC 12391239m

KRConsumer Sentiment Ind*

Actual

Forecast

Previous

94 bln $

January 24 00:30 UTC 14491449m

JPNikkei Mfg PMI

Actual

Forecast

Previous

52.4 %

Close

Welcome to EconoTimes

Sign up for daily updates for the most important
stories unfolding in the global economy.