Professor of Biomedical Engineering, Johns Hopkins University
I did the first experiments showing altered DNA methylation in cancer. I showed that epigenetic changes (chemical changes other than DNA sequence per se) cause cancer are not simply consequential to it through my studies of the disorder Beckwith-Wiedemann syndrome. Later I had the first NIH funded epigenome center. More recently I have developed the idea the genetic variants can control epigenetic stochasticity (plasticity) and phenotype (traits) under evolutionary selection in natural populations, or within an individual in the development of cancer.
Gold Price Holds Above $4,130 as Fed Rate Outlook and Middle East Tensions Support Safe-Haven Demand