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Claire Booth

Professor of Gene Therapy and Paediatric Immunology, UCL
Claire is Professor of paediatric immunology and gene therapy at UCL Great Ormond Street Hospital Institute of Child Health in London and leads the clinical stem cell gene therapy programme at Great Ormond Street Hospital. She is a clinical academic leading an expanding number of gene therapy clinical trials for patients with immune deficiencies, haematological and metabolic disorders. Her research is focused on developing novel therapies for immune system disorders using innovative gene modification techniques. She has extensive experience of translating, leading, and delivering first in human clinical trials and the commercialisation pathway. As an attending physician she oversees the clinical management of patients with immune deficiencies, including hematopoietic stem cell transplantation and maintains a strong interest in HLH disorders.
Claire is an elected board member of the European and American Societies of Gene and Cell Therapy, serves on the editorial board of several journals and grant review committees and holds an honorary position at Boston Children’s Hospital and Harvard Medical School.
She is also the co-founder of the AGORA initiative (Access to Gene therapies fOr Rare disease) which brings together European academic developers and patient organisations, aiming to facilitate access to effective gene therapies for treatment of patients with ultra-rare diseases.

No commercial incentive to develop gene therapy – hospitals will try to fill the gap

Jun 13, 2024 06:12 am UTC| Insights & Views Business

Individually, rare diseases are rare, but there are so many rare diseases that over 400 million people are affected worldwide. Together, rare diseases arent so rare. Only 5% of rare diseases have an approved treatment...

Economy

US Stocks Rise Ahead of Fed Rate Decision

U.S. stocks opened higher on Wednesday, snapping back after six declines in the previous seven sessions as easing oil prices provided some relief ahead of a closely watched Federal Reserve interest rate decision. At 9:32...

Vietnam, U.S. Firms Plan 29 Deals Across Energy, Tech and Aviation

Vietnamese and U.S. companies are expected to announce a broad package of commercial agreements covering energy, technology, aviation and financial services next week as Vietnamese leader To Lam visits New York. An...

UK Inflation Rises to 3.1% Ahead of BoE Rate Decision

UK inflation accelerated in August, adding pressure on households and policymakers just one day before the Bank of England is expected to announce its latest interest rate decision. Official figures released Wednesday...

Asian Currencies Subdued as Yen Slides Ahead of Fed, BOJ Decisions

Asian currencies traded mostly cautiously on Wednesday as the Japanese yen weakened to a one-week low and the U.S. dollar remained near multi-week highs ahead of key Federal Reserve and Bank of Japan policy decisions. The...

Saudi Arabia Raises Security Alerts as Houthi Attacks Threaten Oil Routes

Saudi Arabia issued widespread security alerts on Tuesday, including in Mecca and Jeddah, as attacks by Iran-aligned groups intensified and raised fresh concerns over Middle East oil supplies and Red Sea shipping. The...

Politics

Guterres Urges Stronger Global AI Safeguards Ahead of UN Assembly

United Nations Secretary-General Antonio Guterres warned world leaders on Wednesday that the rapid development of artificial intelligence carries significant risks that governments cannot afford to overlook, highlighting a...

Rodrigo Duterte Makes First Public Appearance at ICC in 18 Months

Former Philippine President Rodrigo Duterte appeared before the International Criminal Court (ICC) on Wednesday, marking his first public appearance since being transferred to The Hague 18 months ago to face murder charges...

US Confirms Weapons in Orbit as Space Tensions Rise

The United States has publicly acknowledged operating weapons in Earths orbit, marking a major shift in how the Pentagon discusses military capabilities in space as competition with China and Russia intensifies. U.S. Air...

South Korea’s Cho Hyun to Meet Rubio in Washington

South Korean Foreign Minister Cho Hyun will travel to Washington this week for talks with U.S. Secretary of State Marco Rubio, as Seoul and Washington seek to maintain close coordination on their bilateral alliance, the...

Ovechkin Faces Scrutiny Over United Russia Campaign Video

Washington Capitals star Alexander Ovechkin has drawn renewed attention over his political ties after appearing in a campaign video connected to United Russia, the ruling party backed by Russian President Vladimir Putin....

Science

Blue Origin New Glenn Explosion Could Delay Launch Operations Until 2028

Blue Origin is facing a significant setback after a dramatic explosion involving its New Glenn rocket severely damaged a launch pad at Cape Canaveral, Florida. According to NASA Administrator Jared Isaacman, repairs to the...

Blue Origin New Glenn Rocket Explodes During Launch Pad Test, Delaying Space Ambitions

Blue Origin suffered a major setback after its uncrewed New Glenn rocket exploded during a launch pad test in Florida on Thursday, raising new challenges for Jeff Bezos space company as it competes with Elon Musks SpaceX...

SpaceX Delays Starship V3 Launch Ahead of Potential Record IPO

SpaceX on Thursday postponed the highly anticipated launch of its 12th Starship rocket test from Texas after technical issues interrupted the final countdown. The company now plans to attempt the Starship V3 launch again...

Trump Administration Releases New UFO Files and Apollo Mission Records

The U.S. Defense Department has released dozens of previously classified UFO-related files following an order from President Donald Trump, sparking renewed debate over unidentified anomalous phenomena (UAP) and government...

China vs. NASA: The New Moon Race and What's at Stake by 2030

The space race is back and this time, its a direct competition between the United States and China for dominance on the lunar surface. NASAs Artemis II mission recently made history when four astronauts flew farther into...

Technology

Databricks to Invest $350 Million in Singapore AI Expansion

Databricks plans to invest more than $350 million in Singapore over the next three years, expanding its presence in the city-state as demand rises for its data and artificial intelligence products. The privately held data...

SK Hynix, Intel Discuss U.S. Memory Chip Production Deal

SK Hynix is reportedly in discussions with Intel over a potential agreement to manufacture memory chips in the United States, a move that would mark the South Korean semiconductor giants first U.S.-based memory production....

DOJ Will Investigate AI-Related Crimes, Attorney General Blanche Says

U.S. Attorney General Todd Blanche said the Department of Justice will investigate individuals or companies connected to artificial intelligence when there is evidence they have violated federal criminal law, while...

Meta CEO Zuckerberg Backs Independent AI Safety Reviews Over Development Slowdown

Meta CEO Mark Zuckerberg has argued that artificial intelligence companies should prioritize independent safety evaluations and stronger alignment rather than slowing the pace of AI development. Zuckerberg said AI...

Nvidia CEO Jensen Huang Expected at Trump-Xi State Dinner

Nvidia CEO Jensen Huang is expected to attend a state dinner hosted by U.S. President Donald Trump for Chinese President Xi Jinping next week, placing one of the technology industrys most prominent executives at the center...