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Andrea Kasinski

Associate Professor of Biological Sciences, Purdue University
Greater than 90% of the human genome is transcribed, yet the functional role for most transcripts is unknown. Many of these unknown transcripts fall into a class of RNAs referred to as non-coding RNAs. The general goal of the Kasinski Lab is to determine the molecular contribution of non-coding RNAs (microRNAs, lncRNA, circRNAs) in normal and disease cells, and to capitalize on this knowledge through developing RNA-based therapeutics. The current projects in the Kasinski lab are subdivided into the following:

Project 1: Ligand-mediated delivery of therapeutically relevant small RNAs
Project 2: Endogenous delivery of RNAs through secreted extracellular vesicles (ie. exosomes)
Project 3: High throughput screening for small molecule inhibitors that alter miRNA biogenesis
Project 4: Identification of miRNAs and protein-coding genes mediating drug resistance

MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

Oct 08, 2024 12:01 pm UTC|

When Victor Ambros and Gary Ruvkun discovered a new molecule they called microRNA in the 1980s, it was a fascinating diversion from what for decades had been called the central dogma of molecular biology. Recognized...

MicroRNA is the master regulator of the genome − researchers are learning how to treat disease by harnessing the way it controls genes

Nov 30, 2023 00:45 am UTC| Science

The Earth formed 4.5 billion years ago, and life less than a billion years after that. Although life as we know it is dependent on four major macromolecules DNA, RNA, proteins and lipids only one is thought to have been...

Economy

Fisker’s Bankruptcy Approved with Added $2.5 Million Tech Support for EV Owners

Fiskers bankruptcy plan has been approved, with an additional $2.5 million committed to providing crucial tech support for Ocean EV owners. The agreement ensures vehicle software updates, diagnostic data, and remote access...

Israeli Strikes Kill 29 in Gaza as Conflict Intensifies in Jabalia

Israeli Military Strikes in Gaza: 29 Palestinians Killed Amid Escalation in Jabalia Gaza, October 13, 2024 Ongoing Israeli airstrikes in Gaza on Saturday have resulted in the deaths of at least 29 Palestinians,...

Hilton Hotel Workers Strike in Seattle: Demands for Fair Wages and Better Conditions

In Seattle, more than 100 Hilton hotel workers have walked off the job, demanding fair wages, balanced workloads, and the reversal of staffing cuts made during the COVID-19 pandemic. The strike, led by the Unite Here...

China Announces Financial Stimulus, But Investors Await More Details

Chinas much-anticipated financial stimulus announcement on Saturday aimed to revive its slowing economy, but investors were left wanting more concrete details. While Finance Minister Lan Foan reiterated Beijings commitment...

Kamala Harris Releases Health Report, Highlights Transparency in Presidential Campaign

Vice President Kamala Harris, the Democratic presidential nominee, released a letter from her physician on Saturday, confirming her robust health and fitness for high office. This move contrasts sharply with her Republican...

Politics

Clear Winner? Donald Trump’s Stunning 5-Point Lead Over Kamala Harris: ‘America Is Ready for a Change!’ Says Former President

In a major boost for his 2024 presidential campaign, Donald Trump is now leading Vice President Kamala Harris by 5 points in the critical battleground state of Arizona. According to a new poll conducted by Siena Research...

Donald Trump’s Bombshell: ‘I’m Going on Joe Rogan’s Show – It’s Going to Be Huge'

Former President Donald Trump has confirmed that he will be appearing on Joe Rogans popular podcast, a move that is already sparking intense speculation and anticipation across political and media circles. The upcoming...

Republicans Now Lead in Voter Registration: ‘First Time in North Carolina’s History – The Democrats Are in Trouble'

For the first time in North Carolinas presidential election history, Republicans have surpassed Democrats in active voter registration. According to data shared by political analyst Michael Pruser, the Republican Party has...

Jim Cramer Doubles Down: ‘I Don’t See How Donald Trump Wins’ the 2024 Election – Shocking Prediction from the Mad Money Host

Jim Cramer, the host of Mad Money and a financial pundit known for his bold, and sometimes inaccurate, predictions, has thrown another controversial opinion into the political arena. In a recent segment, Cramer confidently...

Medal of Honor Recipients Endorse Donald Trump: ‘He’s the Leader America Desperately Needs’

In a powerful show of support, fifteen Medal of Honor recipients have officially endorsed Donald Trump for the 2024 presidential election. These decorated veterans, who represent some of the highest honors in the military,...

Science

SpaceX Warns $4 Million Daily Loss If Starship Launches Are Halted Due to Lawsuit

SpaceX could lose $4 million per day if a lawsuit halts Starship launches in Texas. The lawsuit, filed by environmental group Save RGV, challenges SpaceXs water deluge system. The company argues that delays would impact...

FAA Clears SpaceX Falcon 9 for Launches After Resolving Starlink and NASA Mission Mishaps

The FAA has authorized SpaceXs Falcon 9 rocket to resume routine launches following an investigation into three mishaps, including a second-stage engine failure and a failed booster landing during Starlink and NASA...

SpaceX Gears Up for Starship Flight 5 Launch, With Key Preparations Underway in Texas

SpaceX is finalizing preparations for Starship Flight 5, scheduled for October 13. Teams were seen installing the flight termination system, a key pre-launch step, indicating imminent launch activity. Local authorities in...

SpaceX Prepares for Starship Flight 5, Tower Catch Planned After Successful Tank Tests

After successful tank tests, SpaceX is gearing up for Starship Flight 5 in Texas. The company confirmed plans for the first-ever Super Heavy booster tower catch, pending regulatory approval. The flight marks a key...

SpaceX Activates Starlink Texting for T-Mobile in Florida as Hurricane Milton Approaches

SpaceX has activated Starlink texting for T-Mobile customers in Florida ahead of Hurricane Milton. This service allows users to send messages, including emergency texts to 911, using Starlinks satellite network, ensuring...

Technology

Nintendo Switch 2 to Host New Pokémon Game: Massive Leak Unveils 'Gaia' and MMO Plans

A significant leak from Game Freak has disclosed that a new Pokémon game, codenamed Gaia, is slated for release on Nintendo Switch 2, fueling speculation about an upcoming Pokémon MMO. Pokémon Gen...

2025 Apple Vision Pro: Cheaper Price, Powerful AI—But What's the Catch?

Apple is reportedly gearing up to unveil a significantly cheaper Vision Pro VR headset in the second half of 2025. The new model is expected to feature a plastic chassis, an M5 chipset, and generative AI integration,...

Tesla’s $79,990 Cybertruck Struggles to Attract Buyers, Reservation List Clears Out in 9 Days

Teslas Cybertruck reservation list for U.S. buyers ran out in just nine days after delivery invites began, yet demand for the $79,990 non-Foundation Series appears weaker than expected, sparking questions about the...

Shiba Inu Whales Flee: 1 Trillion SHIB Sold Off as Price Struggles—Is a Crash Coming?

Shiba Inu is facing growing uncertainty as whales offload 1 trillion SHIB in a massive sell-off. With whales retreating and SHIB struggling to break resistance, the market is bracing for potential downward pressure on the...

$1,000 XRP? Experts Say SEC's ETF Approval Could Ignite Unprecedented Price Surge

Financial analysts suggest that XRP could experience an unprecedented price surge to $1,000 following SEC approval of XRP ETFs. The anticipation of institutional funds entering the market is sparking excitement among...