A sugar replacement called erythritol found in Splenda and Equal has been linked by a study to blood clotting, stroke, heart attack, and death.
Erythritolused is used to add bulk or sweeten stevia, monkfruit and keto reduced-sugar products.
Lead study author Dr. Stanley Hazen, director of the Center for Cardiovascular Diagnostics and Prevention at the Cleveland Clinic Lerner Research Institute, warned that “the degree of risk was not modest.”
The study, released on Monday in the journal Nature Medicine, found that people with pre-existing risk factors for heart disease, such as diabetes, were twice as likely to have a heart attack or stroke if they had the highest amounts of erythritol in their blood.
According to Hazen, there was an approximately two-fold increased risk for heart attack and stroke for those whose blood level of erythritol was in the top 25 percent as opposed to the lowest 25 percent. It is comparable to the most serious cardiac risk factors, such as diabetes.
Additional lab and animal research presented in the paper revealed that erythritol appeared to be causing blood platelets to clot more readily. Clots can break off and travel to the heart, triggering a heart attack, or to the brain, triggering a stroke.
Dr. Andrew Freeman, director of cardiovascular prevention and wellness at National Jewish Health, a hospital in Denver, said there appears to be a clotting risk from using erythritol, and that it might make sense to limit erythritol in your diet for now.”
Freeman was not involved in the research.
In response to the study, Robert Rankin, executive director of the Calorie Control Council, an industry association, said that “the results of this study are contrary to decades of scientific research showing reduced-calorie sweeteners like erythritol are safe, as evidenced by global regulatory permissions for their use in foods and beverages.”
Rankin added that the results “should not be extrapolated to the general population, as the participants in the intervention were already at increased risk for cardiovascular events.”


Why financial hardship is more likely if you’re disabled or sick
Parents abused by their children often suffer in silence – specialist therapy is helping them find a voice
Canada Loses Measles-Free Status After Nearly 30 Years Amid Declining Vaccination Rates
Trump’s Approval of AI Chip Sales to China Triggers Bipartisan National Security Concerns
Fed Near Neutral Signals Caution Ahead, Shifting Focus to Fixed Income in 2026
SK Hynix Considers U.S. ADR Listing to Boost Shareholder Value Amid Rising AI Chip Demand
Trump Backs Review of U.S. Childhood Vaccine Schedule After Hepatitis B Policy Change
Samsung SDI Secures Major LFP Battery Supply Deal in the U.S.
EU Court Cuts Intel Antitrust Fine to €237 Million Amid Long-Running AMD Dispute
Intel’s Testing of China-Linked Chipmaking Tools Raises U.S. National Security Concerns
Pfizer Boosts Bid for Metsera Amid Intensifying Rivalry with Novo Nordisk in Obesity Drug Market
Pfizer Secures $10 Billion Deal for Obesity Drug Developer Metsera, Outbids Novo Nordisk
US Signals Openness to New Trade Deal as Brazil Shows Willingness, Says USTR Greer
Glastonbury is as popular than ever, but complaints about the lineup reveal its generational challenge
Air Transat Reaches Tentative Agreement With Pilots, Avoids Strike and Restores Normal Operations
Eli Lilly’s Weight-Loss Pill Nears Fast-Track FDA Approval as Profits Surge on Global Demand
Air Force One Delivery Delayed to 2028 as Boeing Faces Rising Costs 



